[Pharmacokinetics of albendazole and its metabolites in human body]

High-performance liquid chromatography method was used to determine blood sulfoxide and sulfone, two metabolites of albendazole. Methanol containing 0.4% acetic acid was employed as mobile phase. Wavelength of 290 nm was chosen for uv-detector and mebendazole was used as internal standard. After a single dosage of albendazole 25 mg/kg was taken orally by healthy volunteers and neurocysticercosis patients, sulfoxide and sulfone were found in blood at 20 and 40 min respectively. The blood peak level appeared at 6 h on an average. The metabolites remained as long as 58-72 h in human blood.