Related Experiment Video
Updated: May 7, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Oral bisphosphonates and the risk of colorectal cancer: a meta-analysis
Guorong Yang1, Huabin Hu, Ruolan Zeng
1*Department of Oncology, Xiangya Hospital, Central South University, Changsha †Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.
Aim:
: To conduct a meta-analysis on the relationship between the usage of bisphosphonates and the risk of colorectal cancer.
Methods:
We searched PUBMED and EMBASE for studies assessing colorectal cancer incidence or prevalence in bisphosphonate users versus nonusers that were published before August 2012. We used the STATA software to calculate the pooled odds ratios (OR) and 95% confidence interval (CI) for the risk of colorectal cancer associated with exposure to bisphosphonates using a random-effects model.
Results:
Eight studies met our inclusion criteria, which comprised 5 cohort studies and 3 case-control studies, with a total of 22,291 colorectal cancer cases. The usage of bisphosphonates was associated with a statistically significant decrease in colorectal cancer risk, with a pooled OR of 0.89 (95% CI, 0.80-0.99). A statistically significant decrease in the risk of colorectal cancer was observed in the long-term exposure groups (pooled OR, 0.73; 95% CI, 0.57-0.93).
Conclusions:
These results indicate that the decrease in risk of colorectal cancer may be associated with the usage of bisphosphonates. More studies are needed to confirm the relationship.
Related Concept Videos
Cancer Prevention
Some...
Drugs for Treatment of Ulcerative Colitis in IBD
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
