Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced risk of thrombosis in aged insulin-treated diabetic rats exposed to non-severe recurrent hypoglycemia.

Diabetology & metabolic syndrome·2025
Same author

Recurrent hypoglycemia exposure increases the risk of platelet activation and thrombosis in insulin-treated diabetic rats.

Diabetes, obesity & metabolism·2025
Same author

Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis.

Pharmacological reports : PR·2025
Same author

Red Blood Cell Microparticles Limit Hemorrhage Following Intracerebral Hemorrhage in Spontaneously Hypertensive Rats.

Stroke·2023
Same author

Red Cell Microparticles Suppress Hematoma Growth Following Intracerebral Hemorrhage in Chronic Nicotine-Exposed Rats.

International journal of molecular sciences·2022
Same author

Red Blood Cell Microparticles Limit Hematoma Growth in Intracerebral Hemorrhage.

Stroke·2022

Related Experiment Video

Updated: May 7, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Red cell-derived microparticles (RMP) as haemostatic agent.

Wenche Jy1, Max E Johansen, Carlos Bidot

  • 1Wenche Jy, PhD, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB 7109, R36-A, Miami, FL 33136, USA, Tel.: +1 305 243 6617, Fax: +1 305 243 5957,

Thrombosis and Haemostasis
|September 14, 2013
PubMed
Summary

Red cell-derived microparticles (RMP) enhance both platelet function and blood coagulation. These findings suggest RMP hold potential as a novel hemostatic agent for treating bleeding disorders.

Keywords:
Animal bleeding modelsRMP–platelet interactionhaemostatic agentred cell microparticles (RMP)thromboelastography

More Related Videos

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
06:36

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Published on: April 9, 2013

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Related Experiment Videos

Last Updated: May 7, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
06:36

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Published on: April 9, 2013

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Area of Science:

  • Hematology
  • Biomaterials

Background:

  • Red cell-derived microparticles (RMP) are understudied circulating cell-derived microparticles.
  • Investigating RMP's hemostatic potential could offer new therapeutic avenues.

Purpose of the Study:

  • To develop a method for producing RMP in quantity.
  • To characterize the hemostatic properties of RMP.

Main Methods:

  • RMP were generated using high-pressure extrusion of red blood cells (RBC).
  • Characterization involved flow cytometry, light scattering analysis, platelet aggregometry, and thrombin generation assays.
  • Ex vivo and in vivo studies assessed RMP's efficacy in bleeding models and patient samples.

Main Results:

  • RMP (0.45 µm mean diameter) contain procoagulant phospholipids but lack detectable tissue factor.
  • RMP enhanced platelet adhesion and aggregation.
  • RMP improved hemostasis in patient blood samples and reduced blood loss in animal models.

Conclusions:

  • RMP exhibit broad hemostatic activity, supporting both primary and secondary hemostasis.
  • RMP demonstrate potential as a therapeutic agent for managing bleeding conditions.