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Hyponatraemia induced hyperCKaemia.

Ketki Khandhadiya¹, Krishnananda Prabhu, K N Shivashankara

¹Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

BMJ Case Reports

|September 14, 2013

Summary

This summary is machine-generated.

A rare case of hyponatremia-induced myopathy causing high creatine kinase (CK) levels was observed. Prompt treatment of low sodium (hyponatremia) resolved the muscle issue and elevated CK levels.

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Area of Science:

Neurology
Endocrinology
Biochemistry

Background:

Hyponatremia, a condition of low serum sodium, can present with diverse neurological symptoms.
Elevated creatine kinase (CK) levels typically indicate muscle damage, but its association with hyponatraemia is less common.

Observation:

A 32-year-old woman presented with gastroenteritis symptoms and a generalized tonic-clonic seizure.
Investigations revealed severe hyponatremia (low serum sodium) and significantly elevated creatine kinase (CK) levels.
Neurological examination and other baseline tests were largely unremarkable.

Findings:

The patient was treated for hyponatremia with intravenous fluids and a high-salt diet.
Following correction of hyponatremia, creatine kinase (CK) levels normalized.
This suggested a diagnosis of hyponatremia-induced myopathy as the cause of hyperCKaemia.

Implications:

This case highlights a rare but potentially serious complication of hyponatremia.
Early recognition and management of hyponatremia are crucial to prevent or reverse myopathy.
Clinicians should consider hyponatremia as a potential cause of unexplained hyperCKaemia, especially in patients with neurological symptoms.