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Related Experiment Video

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Bilateral nevus comedonicus syndrome.

Takamichi Ito¹, Yasutaka Mitamura, Yayoi Tsuji

¹Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan ; †Department of Dermatology, National Hospital Organization Kyushu Medical Center, Fukuoka 810-0065, Japan.

Yonago Acta Medica

|September 14, 2013

Summary

This case report details an unusual presentation of bilateral nevus comedonicus syndrome in a 62-year-old man, highlighting diverse systemic complications and treatment resistance.

Keywords:

nevus comedonicus nevus comedonicus syndrome schwannoma thyroid tumor

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Area of Science:

Dermatology
Medical Genetics

Background:

Nevus comedonicus is a rare follicular malformation.
It can present unilaterally or bilaterally, sometimes associated with systemic conditions (nevus comedonicus syndrome).

Purpose of the Study:

To report an unusual case of disseminated bilateral nevus comedonicus with systemic complications.
To discuss the diagnostic challenges and appropriate classification for such complex cases.

Main Methods:

Case presentation of a 62-year-old Japanese man with a 50-year history of lesions.
Clinical examination, histopathologic analysis, and review of patient's extensive medical history.
Assessment of treatment response to topical retinoic acid and activated vitamin D3.

Main Results:

The patient exhibited widespread, symmetric comedo-like papules following Blaschko's lines.
Significant systemic comorbidities included thyroid cancer, pneumothorax, spinal abnormalities, and atrial fibrillation.
Topical treatments showed no improvement in the skin lesions.

Conclusions:

The patient's condition was diagnosed as bilateral nevus comedonicus syndrome, representing a unique presentation.
This case underscores the variability of nevus comedonicus and its potential for extensive systemic involvement.
Further research is needed to understand the pathogenesis and optimal management of complex nevus comedonicus syndrome cases.