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Updated: May 7, 2026
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Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster
Published on: March 14, 2019
Bovine papillomavirus type 4 L1 gene transfection in a Drosophila S2 cell expression system: absence of L1 protein
Luiz Gustavo Bentim Góes1, Antonio Carlos de Freitas, Oilita Pereira Ferraz
1Laboratório de Genética, Instituto Butantan , São Paulo, SP , Brasil.
Abstract:
The development of a bovine papillomavirus (BPV) vaccine is an outstanding challenge. BPV protein L1 gene transfection in the Drosophila melanogaster S2 cell expression system failed to produce L1 protein notwithstanding correct L1 gene insertion. Severe genetic inbalance in the host cell line, including cytogenetic alterations, may account for the lack of protein expression.
