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Updated: May 7, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Mechanisms and significance of fungicide resistance
Holger B Deising1, Sven Reimann, Sérgio F Pascholati
1Martin-Luther-University, Faculty of Natural Sciences III, Institute of Agricultural and Nutritional Sciences, Phytopathology and Plant Protection , Halle (Saale) , Germany;
Abstract:
In this review article, we show that occurrence of fungicide resistance is one of the most important issues in modern agriculture. Fungicide resistance may be due to mutations of genes encoding fungicide targets (qualitative fungicide resistance) or to different mechanisms that are induced by sub-lethal fungicide stress. These mechanisms result in different and varying levels of resistance (quantitative fungicide resistance). We discuss whether or not extensive use of fungicides in agricultural environments is related to the occurrence of fungicide resistance in clinical environments. Furthermore, we provide recommendations of how development of fungicide resistant pathogen populations may be prevented or delayed.
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