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Postantibiotic effects and postantibiotic sub-MIC effects of tilmicosin, erythromycin and tiamulin on

Liping Wang1, Yuanshu Zhang

  • 1College of Veterinary Medicine, Nanjing Agricultural University , Nanjing 210095 , China.

Brazilian Journal of Microbiology : [Publication of the Brazilian Society for Microbiology]
|September 14, 2013
PubMed

Insights

Tilmicosin and tiamulin showed longer postantibiotic effects (PAE) and postantibiotic sub-MIC effects (PA SME) against Streptococcus suis than erythromycin. These findings aid in controlling resistant S. suis infections and rational drug use.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Pharmacodynamics

Background:

  • Streptococcus suis infections pose a significant threat in animal health.
  • Erythromycin resistance in S. suis is an emerging concern.
  • Understanding antimicrobial pharmacodynamics is crucial for effective treatment.

Purpose of the Study:

  • To investigate the postantibiotic effects (PAE) and postantibiotic sub-MIC effects (PA SME) of tilmicosin, erythromycin, and tiamulin.
  • To compare these effects on both erythromycin-susceptible and resistant S. suis strains.
  • To evaluate the influence of drug concentration on PAE and PA SME.

Main Methods:

  • In vitro investigation of PAE and PA SME.
  • Exposure of Streptococcus suis strains (erythromycin-susceptible and resistant) to tilmicosin, erythromycin, and tiamulin.
  • Measurement and comparison of PAE and PA SME durations.

Main Results:

  • Tilmicosin and tiamulin demonstrated significantly longer PAE and PA SME than erythromycin against both susceptible and resistant S. suis strains.
  • The duration of PAE and PA SME was dose-dependent.
  • PA SME were consistently longer than PAE on S. suis, irrespective of the antimicrobial agent used.

Conclusions:

  • Tilmicosin and tiamulin exhibit superior postantibiotic activity against S. suis compared to erythromycin.
  • PAE and PA SME data can inform strategies for controlling erythromycin-resistant S. suis infections.
  • These findings offer valuable insights for rational antimicrobial drug use in clinical settings.
Keywords:
Postantibiotic effectserythromycinerythromycin-resistant Streptococcus suispostantibiotic sub-MIC effectstiamulintilmicosin

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