Antimicrobial susceptibility of Clostridium perfringens isolated from piglets with or without diarrhea in Brazil
Related Experiment Video
Updated: May 7, 2026
A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence
Published on: October 11, 2018
Felipe Masiero Salvarani1, Rodrigo Otávio Silveira Silva, Prhiscylla Sadanã Pires
1Universidade Federal de Minas Gerais, Departamento de Medicina Veterinária Preventiva, Laboratório de Bacteriose e Pesquisa , Belo Horizonte, MG , Brasil.
Abstract:
The minimum inhibitory concentration (MIC) was determined for 13 antibiotics against Clostridium perfringens isolated from Brazilian piglets. The collection of isolates was performed in June to October 2010. All isolates were susceptible to amoxicillin and ceftiofur, whereas most were resistant to tetracycline and lincomycin. Avilamycin and narasin were more effective against isolates from non-diarrheic than from diarrheic piglets. The other antimicrobials were less active in need of high concentrations to inhibit the growth of the C. perfringens type A. These results suggest the need for further studies evaluating molecular factors related to the antimicrobial resistance of C. perfringens.
Insights
This study assessed antibiotic resistance in Clostridium perfringens from piglets. Most isolates were sensitive to amoxicillin but resistant to tetracycline, highlighting the need for further antimicrobial resistance research.
Area of Science:
- Veterinary Microbiology
- Antimicrobial Resistance
- Swine Health
Background:
- Clostridium perfringens is a significant pathogen in swine, causing considerable economic losses.
- Antimicrobial resistance in C. perfringens poses a threat to animal health and public health.
- Understanding the susceptibility patterns of C. perfringens is crucial for effective treatment strategies.
Purpose of the Study:
- To determine the minimum inhibitory concentration (MIC) of 13 antibiotics against Clostridium perfringens isolates from Brazilian piglets.
- To evaluate potential differences in antimicrobial susceptibility between isolates from diarrheic and non-diarrheic piglets.
Main Methods:
- Antibiotic susceptibility testing was performed on Clostridium perfringens isolates.
- Minimum Inhibitory Concentrations (MICs) were determined for 13 different antimicrobial agents.
- Isolates were collected from piglets in Brazil between June and October 2010.
Main Results:
- All C. perfringens isolates were susceptible to amoxicillin and ceftiofur.
- A high prevalence of resistance was observed against tetracycline and lincomycin.
- Avilamycin and narasin showed greater efficacy against isolates from non-diarrheic piglets compared to diarrheic ones.
- Other tested antimicrobials required high concentrations for growth inhibition of C. perfringens type A.
Conclusions:
- Significant variability exists in the antimicrobial susceptibility profiles of C. perfringens in Brazilian swine.
- The findings underscore the need for judicious antimicrobial use in swine production.
- Further research into the molecular mechanisms of antimicrobial resistance in C. perfringens is warranted.
