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Related Experiment Video

Updated: May 7, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
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Published on: June 17, 2025

Diffuse intrapulmonary neuroendocrine cell hyperplasia.

Anna Louise McGuire, Donna E Maziak, Harman S Sekhon

    Canadian Respiratory Journal
    |September 14, 2013
    PubMed
    Summary

    Diffuse intrapulmonary neuroendocrine cell hyperplasia, a rare lung lesion, may precede typical carcinoid tumors. This report details a case of hyperplasia associated with a primary lung carcinoid tumor.

    Area of Science:

    • Pulmonology
    • Oncology
    • Pathology

    Background:

    • Diffuse intrapulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare condition, potentially preceding typical pulmonary carcinoid tumors.
    • Fewer than 50 cases of DIPNECH have been documented globally.
    • The pathogenesis, clinical significance, and management of DIPNECH remain subjects of ongoing debate.

    Observation:

    • This report presents a case of a patient diagnosed with DIPNECH.
    • The patient also had a co-existing primary typical carcinoid tumor of the lung.

    Findings:

    • The case highlights the association between DIPNECH and a primary pulmonary carcinoid tumor.
    • This association provides further insight into the potential precursor role of DIPNECH.

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    Implications:

    • Understanding the link between DIPNECH and carcinoid tumors is crucial for accurate diagnosis.
    • Further research into DIPNECH pathogenesis may clarify its clinical significance and guide management strategies.
    • This case contributes to the limited literature on DIPNECH, aiding future clinical and research efforts.