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Reference values: Bhattacharya or the method proposed by the IFCC?

W P Oosterhuis1, T A Modderman, C Pronk

  • 1Diakonessenhuis Refaja, Dordrecht, The Netherlands.

Annals of Clinical Biochemistry
|July 1, 1990
PubMed
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The Bhattacharya method provides reference values from patient data, comparable to blood donor data. Differences highlight the impact of statistical methods and population variations on reference value determination.

Area of Science:

  • Clinical Chemistry
  • Biostatistics
  • Population Health

Background:

  • Establishing accurate reference values is crucial for clinical diagnostics.
  • International Federation of Clinical Chemistry (IFCC) provides guidelines for reference value determination.
  • Unselected patient data and blood donor data represent different population groups.

Purpose of the Study:

  • To compare reference values derived from unselected patient data using the Bhattacharya method with those from blood donor data.
  • To evaluate the utility of the Bhattacharya method for determining reference values.
  • To assess the influence of statistical methods and population differences on reference values.

Main Methods:

  • The Bhattacharya method was employed to calculate reference values from unselected patient data.

Related Experiment Videos

  • Reference values were also obtained from a blood donor population, adhering to IFCC recommendations.
  • Statistical comparison of the two sets of reference values was performed.

    • Main Results:

    • Reference values calculated using the Bhattacharya method from patient data differed from those derived from blood donor data.
    • Observed discrepancies were attributed to variations in statistical approaches and population characteristics.
    • The Bhattacharya method demonstrated potential utility, albeit with certain limitations.

    Conclusions:

    • The Bhattacharya method can aid in determining reference values and implementing quality control measures.
    • Differences in reference values underscore the importance of considering the underlying population and statistical methodology.
    • Further research may refine the application of the Bhattacharya method in clinical settings.