Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives

Area of Science:

• Nutritional Science
• Oncology
• Molecular Biology

Background:

• Global population aging leads to increased incidence of age-related chronic diseases, including cancer.
• Phytochemicals, plant-derived compounds, demonstrate anticancer properties by influencing key cellular signaling pathways.
• Personalized nutritional strategies require a deeper understanding of phytochemicals' molecular mechanisms.

Purpose of the Study:

• To review current knowledge on dietary phytochemicals with demonstrated antitumor activity.
• To highlight the molecular targets of these phytochemicals.
• To discuss limitations in current research and propose future directions.

Main Methods:

• Literature review of scientific articles.
• Focus on studies detailing molecular targets and mechanisms of action.
• Analysis of research strategies and future prospects in the field.

Main Results:

• Phytochemicals modulate critical cellular signaling pathways involved in cancer.
• Specific phytochemicals exhibit proven antitumor effects through various molecular interactions.
• Identification of key molecular targets provides a basis for understanding their efficacy.

Conclusions:

• Dietary phytochemicals hold significant potential for cancer prevention and therapy.
• Elucidating molecular targets is crucial for developing personalized phytochemical-based supplements.
• Further research is essential to overcome current limitations and advance the field.