Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Restarting Stalled Replication Forks

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...

Restarting Stalled Replication Forks

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...

The Replisome

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...

The Replisome

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Prokaryotes

Replication in Prokaryotes

DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities.

NPJ systems biology and applications·2026

Same author

Cell-cell communication as underlying principle governing color pattern formation in teleost fishes.

Nature communications·2026

Same author

Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance.

Nature communications·2025

Same author

Single-molecule methods for characterizing receptor dimers reveal metastable opioid receptor homodimers that induce functional modulation.

Nature communications·2025

Same author

Inspection paradox and jump detection in glassy systems.

Physical review. E·2025

Same author

Fast and exact stochastic simulations of epidemics on static and temporal networks.

PLoS computational biology·2025

Search research articles

Related Experiment Video

Updated: May 7, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Published on: July 4, 2007

Replicator dynamics with turnover of players.

Jeppe Juul¹, Ardeshir Kianercy, Sebastian Bernhardsson

¹Niels Bohr Institute, Blegdamsvej 17, DK-2100 Copenhagen, Denmark.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|September 17, 2013

Summary

Player turnover in adaptive dynamics games creates a modified replicator equation. This model explains deviations from Nash equilibria in real-world scenarios like auctions.

More Related Videos

The Collective Trust Game: An Online Group Adaptation of the Trust Game Based on the HoneyComb Paradigm

The Collective Trust Game: An Online Group Adaptation of the Trust Game Based on the HoneyComb Paradigm

Published on: October 20, 2022

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

Related Experiment Videos

Last Updated: May 7, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Published on: July 4, 2007

The Collective Trust Game: An Online Group Adaptation of the Trust Game Based on the HoneyComb Paradigm

The Collective Trust Game: An Online Group Adaptation of the Trust Game Based on the HoneyComb Paradigm

Published on: October 20, 2022

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

Area of Science:

Evolutionary Game Theory
Mathematical Biology
Behavioral Economics

Background:

Adaptive dynamics models population evolution based on strategy success.
Existing models often assume a closed, static population.
Real-world populations experience continuous turnover and replacement.

Purpose of the Study:

To investigate the impact of player turnover on adaptive dynamics in games.
To develop a modified replicator equation incorporating population replacement.
To analyze how turnover affects game equilibria and dynamics.

Main Methods:

Formulated a mathematical model for adaptive dynamics with player turnover.
Derived a macroscopic replicator equation with an added turnover term.
Analyzed prototypical games like Rock-Paper-Scissors and two-action games.
Examined empirical data from lowest unique bid auctions.

Main Results:

Player turnover leads to a modified replicator equation with an additional term.
This term alters the stability of Nash equilibria and system dynamics.
The model accurately predicts departures from Nash equilibria in auction data.

Conclusions:

Player turnover is a crucial factor in evolutionary game dynamics.
The derived model provides a framework for understanding real-world strategic behavior.
This approach offers insights into phenomena like lowest unique bid auction outcomes.