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The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...
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Related Experiment Video

Updated: May 7, 2026

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Toward ovine iPSCs.

C Bruce A Whitelaw1

  • 1The Roslin Institute and R(D)SVS, University of Edinburgh , Easter Bush Campus, Edinburgh, Midlothian EH25 9RG, United Kingdom .

Cellular Reprogramming
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Recent advances in induced pluripotent stem cells (iPSCs) offer new possibilities for livestock. This review focuses on ovine iPSCs, crucial for nuclear transfer and ruminant developmental studies.

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Last Updated: May 7, 2026

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Published on: May 14, 2012

Area of Science:

  • Reproductive biology
  • Stem cell science
  • Animal biotechnology

Background:

  • Pluripotent livestock stem cells have been researched for over 20 years.
  • Recent breakthroughs involve induced pluripotent stem cells (iPSCs) generated from somatic cells.
  • Progress varies across species, including porcine, bovine, equine, and ovine.

Purpose of the Study:

  • To review the current status of ovine induced pluripotent stem cells (iPSCs).
  • To discuss the application of ovine iPSCs in improving nuclear transfer efficiency.
  • To highlight the use of ovine iPSCs as an in vitro model for ruminant early development.

Main Methods:

  • Review of existing literature on livestock iPSCs.
  • Analysis of reprogramming techniques for ovine somatic cells.
  • Evaluation of iPSC applications in animal breeding and developmental biology.

Main Results:

  • Significant progress has been made in generating iPSCs across multiple livestock species.
  • Ovine iPSCs show promise for enhancing somatic cell nuclear transfer (SCNT).
  • Development of in vitro systems using ovine iPSCs aids in studying ruminant embryogenesis.

Conclusions:

  • Ovine iPSCs represent a significant advancement in livestock stem cell research.
  • The development of ovine iPSCs is pivotal for both reproductive technologies and fundamental research in ruminants.
  • Further research into ovine iPSCs will likely accelerate progress in animal biotechnology and developmental studies.