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Updated: May 7, 2026

Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent
Carla Minoia1, Carmela Quero, Mariaconsilia Asselti
1Haematology Unit, Department of Medical and Experimetal Oncology, IRCCS National Cancer Research Centre "Giovanni Paolo II", Bari, Italy.
Abstract:
Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
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