Related Experiment Video
Updated: May 7, 2026
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
Different methods of hilar clamping during partial nephrectomy: Impact on renal function
Jeong Woo Lee1, Hwanik Kim, Minsoo Choo
1Department of Urology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Summary
Non-clamping partial nephrectomy shows better immediate renal function compared to clamping methods. However, long-term kidney function is similar across all techniques, emphasizing minimal ischemia time when clamping is necessary.
Area of Science:
- Urology
- Nephrology
- Surgical Oncology
Background:
- Partial nephrectomy is standard for small renal tumors.
- Hilar clamping strategies impact renal function.
- Understanding long-term renal outcomes is crucial.
Purpose of the Study:
- To compare the effects of non-clamping, cold ischemia, and warm ischemia on renal function after partial nephrectomy.
- To evaluate immediate and long-term changes in estimated glomerular filtration rate (eGFR).
Main Methods:
- Retrospective analysis of 369 patients undergoing partial nephrectomy for renal tumors (≤4.0 cm).
- Patients categorized into non-clamping, cold ischemia, and warm ischemia groups.
- eGFR assessed preoperatively, at nadir, and 1 year postoperatively.
Main Results:
- Non-clamping showed significantly less nadir eGFR decline than clamping groups (P < 0.001).
- No significant differences in 1-year eGFR change among groups (P = 0.348).
- Hilar clamping associated with nadir eGFR change, but not 1-year eGFR change.
Conclusions:
- Non-clamping partial nephrectomy preserves immediate renal function better.
- Long-term renal function is comparable across clamping and non-clamping methods.
- Minimizing ischemia time is key when hilar clamping is unavoidable.
