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Relationship between cerebral atherosclerosis and leukoaraiosis in aged patients: results from DSA

Hua Li1, Gelin Xu, Yunyun Xiong

  • 1Department of Neurology, Jinling Hospital, Nanjing, China.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|September 17, 2013
PubMed

Insights

Cerebral artery stenosis, evaluated via digital subtraction angiography (DSA) and MRI, showed no correlation with leukoaraiosis in older adults. Age and hypertension were linked to periventricular leukoaraiosis, while age and prior stroke were linked to deep white matter leukoaraiosis.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Conflicting findings exist regarding the link between cerebral atherosclerosis and leukoaraiosis.
  • Previous studies often used ultrasonography, CTA, or MRA to assess cerebral atherosclerosis.

Purpose of the Study:

  • To investigate the relationship between cerebral artery stenosis and leukoaraiosis in older individuals.
  • To utilize both MRI and digital subtraction angiography (DSA) for comprehensive assessment.

Main Methods:

  • 333 patients from the Nanjing Stroke Registry were included.
  • Cerebral DSA and MRI were performed on all participants.
  • Data on age, sex, vascular risk factors, atherosclerosis grade (0-4), and leukoaraiosis grade (0-3) were collected.

Main Results:

  • No significant correlation was found between cerebral artery stenosis and the presence or severity of leukoaraiosis.
  • No correlation existed between the number of stenotic arteries and leukoaraiosis in periventricular, deep, or whole white matter.
  • Old age and hypertension were associated with periventricular leukoaraiosis.
  • Old age and prior stroke were associated with deep white matter leukoaraiosis.

Conclusions:

  • There is no apparent correlation between cerebral artery stenosis and the presence or severity of leukoaraiosis.
  • Specific risk factors like age, hypertension, and prior stroke are associated with leukoaraiosis in different white matter regions.
Abstract

Keywords:
Leukoaraiosisatherosclerosisdigital subtraction angiographyischemic stroke

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