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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

A single-site retrospective study of pediatric arterial ischemic stroke etiology, clinical presentation, and

Dan Sun1, Xiao-Man Wu, Zeng-Wu Wang

  • 1Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Neurology, Wuhan Children's Hospital, Wuhan, Hubei 430016, China.

Chinese Medical Journal
|September 17, 2013
PubMed

Insights

Pediatric arterial ischemic stroke (PAIS) is more common in younger children, often presenting with convulsions. Etiologies and affected brain regions in children differ from adults, requiring further investigation.

Area of Science:

  • Neurology
  • Pediatrics
  • Radiology

Background:

  • Stroke, characterized by cerebral blood circulation obstruction, typically affects older adults.
  • Pediatric arterial ischemic stroke (PAIS) is a rare but significant neurological event in children.
  • Understanding PAIS is crucial due to its distinct characteristics compared to adult stroke.

Purpose of the Study:

  • To investigate the causes (etiology) of pediatric arterial ischemic stroke (PAIS).
  • To describe the clinical symptoms and presentation of PAIS in children.
  • To identify the radiologic features and locations of neurological deficits in pediatric stroke patients.

Main Methods:

  • Retrospective review of medical records for 42 pediatric patients diagnosed with PAIS.
  • Cerebral infarction locations identified using computed tomography and magnetic resonance (MR) imaging.
  • Arterial stenosis or occlusion assessed via MR angiography and digital subtraction angiography.

Main Results:

  • PAIS predominantly affected younger children (≤ 3 years old), accounting for 66.7% of cases.
  • Convulsions were a more frequent initial symptom in younger children (≤ 3 years), while older children (>3 years) presented with symptoms like hemiparalysis and aphasia.
  • Common etiologies included infections (38.1%), iron deficiency anemia (16.7%), and moyamoya syndrome (11.9%). Predominant infarct locations were the middle cerebral artery and basal ganglia.

Conclusions:

  • Pediatric arterial ischemic stroke (PAIS) occurs more frequently in younger children, with convulsions being a common presenting symptom.
  • The etiologies and affected cerebral regions in PAIS may differ significantly from adult stroke.
  • Further research is needed to fully understand the distinct features of PAIS and its various forms.
Abstract

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