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Endometrial adenocarcinoma in a mare
M K Chaffin1, I C Fuentealba, D G Schmitz
1Texas Veterinary Medical Center, Department of Large Animal Medicine & Surgery, College Station.
The Cornell Veterinarian
|January 1, 1990
Summary
An 11-year-old Arabian mare was diagnosed with advanced endometrial adenocarcinoma. This rare equine cancer metastasized widely, causing severe clinical signs and ascites.
Area of Science:
- Veterinary Pathology
- Equine Oncology
- Comparative Oncology
Background:
- Endometrial adenocarcinoma is a rare malignant uterine neoplasm in mares.
- Metastatic patterns and clinical presentations can vary significantly.
- Early diagnosis and understanding of metastatic potential are crucial for equine health.
Observation:
- An 11-year-old Arabian mare presented with generalized weight loss, depression, anorexia, ventral edema, and abdominal distension.
- Ascites was identified as a consequence of caudal vena cava thrombosis.
- Necropsy revealed widespread metastases of endometrial adenocarcinoma to the lung, liver, spleen, mesentery, and serosal peritoneal surfaces.
Findings:
- Histopathological examination confirmed the primary diagnosis of endometrial adenocarcinoma based on uterine glandular epithelial morphology.
- Metastatic tissues exhibited similar histological characteristics to the primary uterine tumor.
- The extensive metastatic spread highlights the aggressive nature of this equine cancer.
Implications:
- This case underscores the importance of considering advanced endometrial adenocarcinoma in differential diagnoses for mares with unexplained weight loss and ascites.
- Understanding the metastatic potential is critical for prognosis and treatment strategies in equine oncology.
- Further research into risk factors and early detection methods for equine endometrial adenocarcinoma is warranted.