Association between physical activity and serum C-peptide levels among the elderly

Area of Science:

• Gerontology
• Endocrinology
• Exercise Physiology

Background:

• Serum C-peptide, an active peptide, plays a role in elderly physiology.
• Understanding factors influencing C-peptide levels is crucial for aging health research.

Purpose of the Study:

• To investigate the relationship between physical activity and serum C-peptide levels in the elderly.
• To examine this association independent of insulin levels.

Main Methods:

• Included 1700 participants aged 65 years and older.
• Utilized stratified analysis of covariance and multiple linear regression models.
• Analyzed associations stratified by sex, BMI, and serum insulin levels.

Main Results:

• Vigorous physical activity correlated with lower serum C-peptide levels compared to light or no activity.
• A positive association was observed between physical activity and serum C-peptide in individuals with low C-peptide levels (≤ 0.621 nmol/L).
• A negative association was found between physical activity and serum C-peptide in individuals with higher C-peptide levels (>0.621 nmol/L).

Conclusions:

• Serum C-peptide levels exhibit a significant bidirectional association with physical activity in the elderly.
• Modifying physical activity levels may be a key strategy for improving serum C-peptide levels in older adults.