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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Cholecystitis01:20

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Updated: May 7, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Chronic tophaceous gout].

M González-Rozas1, J M Prieto de Paula, S Franco Hidalgo

  • 1Servicio de Medicina Interna, Hospital Clínico de Valladolid, Valladolid, España.

Semergen
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Gout, a crystal-induced arthritis, often stems from hyperuricemia due to poor kidney excretion. Adherence to gout treatment guidelines remains a challenge, impacting patient outcomes.

Keywords:
Artritis gotosaChronic tophaceous goutGotaGota tofácea crónicaGoutGouty arthritisHiperuricemiaHyperuricemia

Related Experiment Videos

Last Updated: May 7, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Nephrology

Background:

  • Gout is a prevalent inflammatory arthritis linked to hyperuricemia, often caused by impaired renal uric acid excretion.
  • The condition disproportionately affects men and increases in prevalence with age.
  • Despite perceived simplicity, clinical adherence to gout management guidelines is suboptimal.

Observation:

  • This report details a clinical case of chronic tophaceous gout.
  • Chronic tophaceous gout involves the deposition of monosodium urate crystals, leading to visible tophi and joint damage.

Findings:

  • Hyperuricemia, a key feature of gout, results from an imbalance between uric acid production and excretion.
  • Recurrent acute gouty arthritis episodes are characteristic, caused by monosodium uric acid crystal deposition in joints.
  • Poor adherence to established diagnostic and treatment protocols complicates effective gout management.

Implications:

  • Improved adherence to clinical guidelines is crucial for managing hyperuricemia and preventing gout flares.
  • Understanding the pathophysiology of gout is essential for developing targeted therapeutic strategies.
  • This case highlights the need for better patient education and physician compliance in chronic gout care.