Pralidoxime in the treatment of carbamate intoxication

¹California Department of Food and Agriculture, Worker Health and Safety Branch, Sacramento 94271-0001.

The American Journal of Emergency Medicine

|January 1, 1990

Abstract:

The use of oxime reactivators of inhibited cholinesterase enzymes in poisoning by carbamate compounds has received mixed reviews in the medical literature. Data are limited and inconsistent on the possible role oxime reactivators might have in carbamate intoxication. Based on existing experience, atropine remains the treatment of choice and pralidoxime (2-PAM) is not recommended except in cases where atropine has first been proven inadequate, in serious mixed poisonings with both carbamate and organophosphorus compounds, or in serious poisonings by unidentified cholinesterase inhibitors.

Related Experiment Videos

Pralidoxime in the treatment of carbamate intoxication

Related Concept Videos

A variant of mass (epidemic) psychogenic illness in the agricultural work setting.

Assessment of potential acute health effects in agricultural workers exposed during the application of chlordimeform.

The appendix where you least expect it: Incarcerated Amyand's hernia - A case report.

Risk of respiratory and neurologic effects in children ingesting kratom and related alkaloids.

Head, neck, and spinal injuries in go-karting: An epidemiological analysis.

Safety and efficacy of tenecteplase versus alteplase for acute ischemic stroke in a real-world patient population.

Case report of the gill slit procedure relieving hypotension due to severe subcutaneous emphysema in a post-cardiac arrest patient.

Airway-threatening lingual hematoma after tongue biting in a hemodialysis patient treated with transcatheter arterial embolization.

Electrophysiological and computational analyses of anethole-induced inhibition of L-type calcium channels in rat tracheal smooth muscle.

Comparative characterization of candidal cell surface-associated phosphoglycerate mutase (Gpm1) - fungal cell wall adsorption and host protein binding across pathogenic Candida species.

Spectrum-effect relationship between chromatography fingerprints and bioactive components of Atractylodes macrocephala on alleviating ulcerative colitis.

Dominant doubly charged ion enabling robust LC-MS/MS quantification of a novel small-molecule antibacterial drug Cefidelbaz in human plasma and its application to pharmacokinetic and protein binding studies.

When dying worms look alike: Convergent pathology may create mechanistic illusion in plant-derived anthelmintic research.

Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.

Related Experiment Videos

Pralidoxime in the treatment of carbamate intoxication

Abstract:

Related Concept Videos

Related Articles