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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: May 7, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Th17-mediated inflammation in asthma.

Dawn C Newcomb1, R Stokes Peebles

  • 1Vanderbilt University Medical Center, Department of Medicine, Nashville, TN 37232, United States.

Current Opinion in Immunology
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

T helper 17 (Th17) cytokines, including IL-17A, IL-17F, and IL-22, are linked to moderate-to-severe asthma. These cytokines promote airway inflammation, neutrophil recruitment, and airway narrowing, with ongoing trials investigating targeted therapies.

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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Related Experiment Videos

Last Updated: May 7, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Asthma is a complex respiratory disease with diverse phenotypes.
  • Moderate and severe asthma are associated with elevated T helper 17 (Th17) cytokines (IL-17A, IL-17F, IL-22) and neutrophils in bronchoalveolar lavage fluid.
  • Th17 cytokines contribute to airway neutrophilia, mucous cell metaplasia, and airway smooth muscle dysfunction, leading to airway narrowing.

Purpose of the Study:

  • To investigate the role of Th17 cytokines in asthma pathogenesis.
  • To explore the relationship between Th17 cytokines and allergic airway inflammation.
  • To understand the impact of Th17 signaling on airway hyperresponsiveness.

Main Methods:

  • Analysis of bronchoalveolar lavage fluid from asthma patients.
  • Assessment of cytokine profiles, including Th17-associated cytokines.
  • Evaluation of neutrophil counts and airway inflammation markers.
  • Review of existing literature and ongoing clinical trial data.

Main Results:

  • Elevated levels of IL-17A, IL-17F, and IL-22 were observed in moderate and severe asthma.
  • Th17 cytokines were found to increase neutrophilic chemokine secretion by airway epithelium.
  • Th17 cytokines demonstrated pleiotropic effects on airway smooth muscle, contributing to narrowing.
  • The precise role of Th17 cytokines in modulating Th2 responses in allergic asthma remains under investigation.

Conclusions:

  • Th17 cytokines play a significant role in the pathophysiology of moderate-to-severe asthma.
  • Targeting IL-17A and its receptor signaling represents a promising therapeutic strategy for asthma.
  • Further research and clinical trials are crucial to fully elucidate the impact of Th17 cells in asthma management.