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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

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Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection

Jason P Lott1, Kristina Liu2, Marie-Louise Landry3

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut; Robert Wood Johnson Foundation Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut.

Journal of the American Academy of Dermatology
|September 17, 2013
PubMed
Abstract

Insights

Atypical hand-foot-and-mouth disease (HFMD) caused by coxsackievirus A6 (CV-A6) presents with widespread skin lesions, sometimes worsening existing dermatitis. Early recognition aids diagnosis and management of this uncommon enterovirus strain.

Area of Science:

  • Virology
  • Dermatology
  • Infectious Diseases

Background:

  • Hand-foot-and-mouth disease (HFMD) is typically caused by coxsackievirus (CV)-A16 and enterovirus 71.
  • Atypical HFMD presentations have recently been associated with the less common enterovirus strain, CV-A6.

Observation:

  • This case series describes clinical features and laboratory findings of atypical HFMD in 5 patients (2 adults, 3 children).
  • Widespread mucocutaneous lesions were observed in 4 out of 5 patients.
  • In patients with atopic dermatitis, lesions were accentuated in affected areas.

Findings:

  • Coxsackievirus A6 (CV-A6) infection was confirmed in all patients via reverse transcriptase polymerase chain reaction and viral capsid protein 1 gene sequencing.
  • Systemic symptoms led 4 patients to seek emergency care, with both adults requiring hospitalization.

Implications:

  • Recognizing the diverse cutaneous manifestations of CV-A6 associated HFMD is crucial for accurate clinical diagnosis.
  • Understanding these atypical presentations can improve patient management strategies for HFMD.
Keywords:
ADCDCCVCenters for Disease Control and PreventionEDHFMDPCRRTatopic dermatitisatypicalcoxsackieviruscoxsackievirus A6diagnosisemergency departmententerovirusevaluationexanthemhand-foot-and-mouth diseasepolymerase chain reactionreverse transcriptase

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