Related Experiment Video
Updated: May 7, 2026
06:36
Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains
Published on: May 19, 2023
A coming of age: advanced imaging technologies for characterising the developing mouse
Francesca C Norris1, Michael D Wong, Nicholas D E Greene
1University College London (UCL) Centre for Advanced Biomedical Imaging, Division of Medicine, UCL, London, UK; Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), UCL, London, UK.
Trends in Genetics : TIG
|September 17, 2013
Summary
Advanced imaging technologies are crucial for mouse genome annotation and understanding essential genes in embryo development. This review guides researchers in selecting optimal imaging techniques for phenotype discovery.
Area of Science:
- Developmental Biology
- Genomics
- Biotechnology
Background:
- Annotating the mouse genome presents a significant challenge, driving innovation in imaging technologies.
- Understanding gene function in embryo development is critical, with at least one-third of genes essential.
- Integrating advanced imaging with biological requirements is key to discovering more phenotypes.
Purpose of the Study:
- To review recent advancements in embryo imaging technologies.
- To examine the relative merits of current and emerging imaging techniques.
- To guide researchers in selecting appropriate embryo imaging technologies.
Main Methods:
- Comprehensive review of imaging technologies over the past decade.
- Analysis of the strengths and weaknesses of various imaging techniques.
- Examination of integrated approaches to embryo phenotyping.
Main Results:
- Rapid progress has been made in imaging technologies for biological research.
- A wide array of techniques exists, each with specific advantages for embryo imaging.
- Informed decisions on technology selection are crucial for maximizing phenotype discovery.
Conclusions:
- State-of-the-art embryo imaging is essential for advancing mouse genome annotation.
- Effective collaboration between imaging experts and researchers is vital.
- This review serves as a guide for selecting optimal imaging technologies and fostering interdisciplinary dialogue.
