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Updated: May 7, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Obstructive sleep apnea is a risk factor for Barrett's esophagus
Cadman L Leggett1, Emmanuel C Gorospe1, Andrew D Calvin2
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Summary
Obstructive sleep apnea (OSA) is linked to a higher risk of Barrett's esophagus (BE), even when accounting for GERD and BMI. Patients with OSA may need screening for BE.
Area of Science:
- Gastroenterology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) and Barrett's esophagus (BE) share risk factors like obesity and GERD.
- The relationship between OSA and BE requires further investigation.
- Understanding this association can inform clinical practice.
Purpose of the Study:
- To assess the association between OSA and BE.
- To determine if the OSA-BE association is independent of GERD and BMI.
- To explore the impact of OSA severity on BE risk.
Main Methods:
- A case-control study matched patients on age, sex, and BMI.
- Included groups with BE only, OSA only, both, or neither.
- Used logistic regression to analyze the association, controlling for GERD and smoking history.
Main Results:
- OSA was associated with an 80% increased risk of BE (OR, 1.8; P = .03).
- This association remained significant after adjusting for age, sex, BMI, GERD, and smoking.
- Higher OSA severity correlated with increased BE risk (OR, 1.2 per 10-unit increase in AHI; P = .03).
Conclusions:
- OSA is independently associated with an increased risk of BE.
- Potential mechanisms may exist beyond BMI and GERD.
- Suggests that patients with OSA should be evaluated for BE.
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