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Parkinson's disease in a dish - Using stem cells as a molecular tool

J L Badger1, O Cordero-Llana, E M Hartfield

  • 1StemBANCC, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Molecular Neurodegeneration Group, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.

Neuropharmacology
|September 17, 2013
PubMed
Summary

Patient-derived induced pluripotent stem cells (iPSCs) offer a powerful way to model Parkinson's disease (PD) in vitro. Studying these cells helps understand disease mechanisms and develop new therapies for this neurodegenerative condition.

Keywords:
Alpha synucleinCMADADATDopaminergic neuronsERGCaseGSHGWASGlucocerebrosidaseHSPB1Induced pluripotent stem cellLRRK2Leucine rich repeat kinase 2MAPTMLKMOAOSPDPINK1PTEN induced kinase 1ParkinParkinson's diseaseTHZFNalpha synucleinchaperone mediated autophagydopaminedopamine active transporterendoplasmic reticulumgenome wide association analysisglucocerebrosidaseglutathione synthasehESCheat shock 27 kDa protein 1human embryonic stem celliPSCinduced pluripotent stem cellleucine rich repeat kinase 2microtubule associated protein taumixed lineage kinasemonoamine oxidaseoxidative stresstyrosine hydroxylasezinc finger nucleaseα-SYN

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