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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
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Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Systemic tumor-specific gene delivery.

Max Kullberg1, Ryan McCarthy, Thomas J Anchordoquy

  • 1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, 12850 Montview Boulevard, Aurora, Colorado 80045, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Achieving targeted cancer gene therapy requires overcoming non-specific delivery to organs like the liver and lungs. This review examines methods to enhance tumor-specific gene expression for improved cancer treatment.

Keywords:
Delivery systemDendrimerGene therapyNon-viralSystemicViral

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Area of Science:

  • Oncology
  • Gene Therapy
  • Nanomedicine

Background:

  • Systemic cancer gene therapy aims for tumor-specific gene expression.
  • Viral and non-viral delivery systems often target the liver and lungs non-specifically.
  • Targeted delivery is crucial for potent therapeutic genes like IL-12 and TNF-alpha.

Purpose of the Study:

  • To review techniques for achieving tumor-specific gene expression via systemic administration.
  • To analyze the effectiveness of various delivery systems and targeting strategies.
  • To identify optimal methods for overcoming off-target organ accumulation.

Main Methods:

  • Analysis of receptor targeting via ligand conjugation.
  • Evaluation of tumor-specific promoter utilization.
  • Review of viral mutation strategies for targeting overexpressed tumor proteins.
  • Assessment of gene delivery systems including liposomes, PEI, dendrimers, stem cells, and viral vectors.

Main Results:

  • Discusses strategies like ligand conjugation, tumor-specific promoters, and viral mutations.
  • Evaluates effectiveness across liposomal, PEI, dendrimer, stem cell, and viral platforms.
  • Highlights challenges in achieving exclusive tumor expression.

Conclusions:

  • Targeting techniques are essential for effective cancer gene therapy.
  • Further research is needed to optimize delivery systems for enhanced tumor specificity.
  • Overcoming off-target organ accumulation is key for aggressive tumor treatment.