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Systemic tumor-specific gene delivery

Max Kullberg1, Ryan McCarthy, Thomas J Anchordoquy

  • 1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, 12850 Montview Boulevard, Aurora, Colorado 80045, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 17, 2013
PubMed

Insights

Achieving targeted cancer gene therapy requires overcoming non-specific delivery to organs like the liver and lungs. This review examines methods to enhance tumor-specific gene expression for improved cancer treatment.

Area of Science:

  • Oncology
  • Gene Therapy
  • Nanomedicine

Background:

  • Systemic cancer gene therapy aims for tumor-specific gene expression.
  • Viral and non-viral delivery systems often target the liver and lungs non-specifically.
  • Targeted delivery is crucial for potent therapeutic genes like IL-12 and TNF-alpha.

Purpose of the Study:

  • To review techniques for achieving tumor-specific gene expression via systemic administration.
  • To analyze the effectiveness of various delivery systems and targeting strategies.
  • To identify optimal methods for overcoming off-target organ accumulation.

Main Methods:

  • Analysis of receptor targeting via ligand conjugation.
  • Evaluation of tumor-specific promoter utilization.
  • Review of viral mutation strategies for targeting overexpressed tumor proteins.
  • Assessment of gene delivery systems including liposomes, PEI, dendrimers, stem cells, and viral vectors.

Main Results:

  • Discusses strategies like ligand conjugation, tumor-specific promoters, and viral mutations.
  • Evaluates effectiveness across liposomal, PEI, dendrimer, stem cell, and viral platforms.
  • Highlights challenges in achieving exclusive tumor expression.

Conclusions:

  • Targeting techniques are essential for effective cancer gene therapy.
  • Further research is needed to optimize delivery systems for enhanced tumor specificity.
  • Overcoming off-target organ accumulation is key for aggressive tumor treatment.
Keywords:
Delivery systemDendrimerGene therapyNon-viralSystemicViral

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