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Related Experiment Videos

Prophylactic tranexamic acid decreases bleeding after cardiac operations.

J C Horrow1, J Hlavacek, M D Strong

  • 1Department of Anesthesiology, Hahnemann University, Philadelphia, Pa.

The Journal of Thoracic and Cardiovascular Surgery
|January 1, 1990
PubMed
Summary

Tranexamic acid, an antifibrinolytic therapy, significantly reduced chest tube drainage and postoperative bleeding in cardiac surgery patients. This treatment is safe and may decrease the need for blood transfusions.

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Area of Science:

  • Cardiovascular Surgery
  • Anesthesiology
  • Hematology

Background:

  • Postoperative bleeding is a significant complication in cardiac surgery.
  • Antifibrinolytic therapy aims to reduce blood loss by inhibiting plasminogen activation.

Purpose of the Study:

  • To evaluate the efficacy of tranexamic acid in reducing chest tube drainage after cardiac operations.
  • To assess the safety and impact of tranexamic acid on blood loss and transfusion requirements.

Main Methods:

  • A randomized trial involving 38 patients undergoing cardiac surgery.
  • Patients received either tranexamic acid or a placebo.
  • Blood loss, fibrin split products, and plasminogen availability were measured.

Main Results:

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  • Tranexamic acid group showed significantly less 12-hour blood loss (496 ml vs. 750 ml).
  • Fibrin split products were less frequent in the tranexamic acid group (p = 0.0002).
  • Plasminogen availability was markedly decreased with tranexamic acid (p = 0.0058).

Conclusions:

  • Prophylactic tranexamic acid is safe for inhibiting fibrinolysis during cardiac surgery.
  • Tranexamic acid effectively decreases postoperative bleeding and may reduce blood product transfusions.
  • No coagulation-related complications were observed in the tranexamic acid group.