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Related Concept Videos

Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Related Experiment Video

Updated: May 7, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

Long-term renal function outcomes after radical cystectomy.

Manuel S Eisenberg1, R Houston Thompson1, Igor Frank1

  • 1Department of Urology, Mayo Clinic, Rochester, Minnesota.

The Journal of Urology
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Most patients experience decreased renal function after radical cystectomy. Modifiable factors like hydronephrosis and pyelonephritis impact kidney function, but urinary diversion type does not.

Keywords:
chroniccystectomypostoperative complicationsrenal insufficiencyurinary bladder neoplasmsurinary diversion

Related Experiment Videos

Last Updated: May 7, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

Area of Science:

  • Urology
  • Nephrology
  • Oncology

Background:

  • Radical cystectomy is a major surgery for bladder cancer.
  • Urinary diversion is necessary after cystectomy, with various types available.
  • Long-term renal function after radical cystectomy requires further investigation.

Purpose of the Study:

  • To evaluate the long-term natural history of renal function following radical cystectomy.
  • To identify factors associated with decreased renal function after this procedure.

Main Methods:

  • Retrospective review of 1,631 patients undergoing radical cystectomy (1980-2006).
  • Calculation of estimated glomerular filtration rate (eGFR) preoperatively and postoperatively.
  • Multivariate analysis to assess associations between clinicopathological features, diversion type, complications, and renal function decrease (defined as >10 ml/min/1.73 m² reduction in eGFR).

Main Results:

  • No significant difference in renal function decrease risk between incontinent and continent diversion by 10 years post-surgery.
  • Key risk factors for decreased renal function included older age, lower preoperative eGFR, chronic hypertension, postoperative hydronephrosis, pyelonephritis, and ureteroenteric stricture.

Conclusions:

  • Decreased renal function is common long-term after radical cystectomy.
  • Postoperative hydronephrosis, pyelonephritis, and ureteroenteric stricture are potentially modifiable risk factors.
  • Urinary diversion type was not an independent predictor of decreased renal function.