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Oxidative modification of serum proteins in multiple sclerosis
Izabela Sadowska-Bartosz1, Monika Adamczyk-Sowa, Sabina Galiniak
1Department of Biochemistry and Cell Biology, University of Rzeszow, ul. Zelwerowicza 4, 35-601 Rzeszów, Poland.
Neurochemistry International
|September 17, 2013
Summary
Oxidative and glycoxidative damage are present in multiple sclerosis (MS). Markers like advanced protein oxidation products (AOPP) can help monitor oxidative stress during MS therapy.
Area of Science:
- Neuroimmunology
- Biochemistry
- Oxidative Stress Research
Background:
- Multiple sclerosis (MS) is associated with oxidative stress and increased glycoxidation.
- Protein modifications due to oxidative and glycoxidative damage are implicated in MS pathogenesis.
Purpose of the Study:
- To compare markers of protein oxidative damage and glycoxidation in different MS patient groups and healthy controls.
- To assess the utility of these markers in monitoring MS and its therapies.
Main Methods:
- Spectrophotometric and fluorimetric analysis of protein oxidation and glycoxidation markers.
- Comparison of marker levels in relapsing-remitting MS patients (untreated, in relapse, treated with interferon β1a, interferon β1b, or glatiramer acetate) and healthy subjects.
Main Results:
- Elevated glycophore content in untreated RRMS patients and those treated with glatiramer acetate.
- Increased advanced protein oxidation products (AOPP) in untreated RRMS patients and those in clinical relapse.
- Correlation of protein modification markers with C-reactive protein and white blood cell count, indicating a link to inflammation.
Conclusions:
- Protein oxidative and glycoxidative damage are confirmed in MS.
- Markers, particularly AOPP, show potential for monitoring oxidative stress during MS treatment.
- Oxidative protein modifications are linked to inflammatory processes in MS.
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