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Updated: May 7, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Design of supramolecular amino acids to template peptide folding
1Department of Chemistry, University of California, Irvine, CA 92697-2025, USA. zguan@uci.edu.
Abstract:
We describe in this manuscript a new design of supramolecular amino acids (SAAs) for directing peptide folding in organic environments. The incorporated supramolecular motif has a strong driving force to dimerize in a sequence- and orientation-specific manner. By introducing such SAAs into the primary sequence of peptides, the specific and directional dimerization of the supramolecular units should facilitate the folding of the peptides. Our approach may provide a general strategy to program secondary structures in organic media.
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