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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Dolichocephaly without sagittal craniosynostosis.

Joel S Beckett1, Miles Jackson Pfaff, Michael Diluna

  • 1From the *Section of Plastic and Reconstructive Surgery and †Department of Neurological Surgery, Yale University School of Medicine, New Haven, CT.

The Journal of Craniofacial Surgery
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Sagittal craniosynostosis, a condition causing abnormal head shape (dolichocephaly), may not always stem from premature sagittal suture closure. This study found patent sutures in patients with dolichocephaly, challenging traditional views.

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Area of Science:

  • Craniofacial Surgery
  • Pediatric Neurosurgery
  • Developmental Biology

Background:

  • Sagittal craniosynostosis is traditionally attributed to premature fusion of the sagittal suture, leading to dolichocephaly.
  • Recent research questions whether suture pathology is the sole or primary cause of this condition.
  • Understanding the etiopathology of abnormal head shapes is crucial for accurate diagnosis and treatment.

Observation:

  • A retrospective case series of 4 patients evaluated for dolichocephaly between 2011 and 2012.
  • Patients presented with physical examinations and cranial indices suggestive of sagittal craniosynostosis.
  • Computed tomographic imaging was performed for all patients.

Findings:

  • Despite clinical suspicion, computed tomographic imaging revealed patent (open) sagittal sutures in all 4 patients.
  • This finding indicates that dolichocephaly can occur without premature fusion of the sagittal suture.
  • The results challenge the established understanding of sagittal craniosynostosis etiology.

Implications:

  • Abnormal head shapes, like dolichocephaly, may have etiologies beyond overt sagittal suture pathology.
  • Further research is needed to elucidate the mechanisms behind non-suture-related dolichocephaly.
  • This challenges traditional diagnostic and treatment paradigms for craniosynostosis.