Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of a
Mauro Felippe Felix Mediano1, Fabiana Alves Neves, Alessandra Cordeiro de Souza Rodrigues Cunha
1Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro (UERJ), Rio de JaneiroRJ, Brazil.
Objective:
Our objective was to evaluate the effects of small-volume, home-based exercise combined with slight caloric restriction on the inflammatory markers C-reactive protein and adiponectin.
Methods:
In total, 54 women were randomly assigned to one of two groups for exercise intervention: the control or home-based exercise groups. Weight, waist and hip circumferences, and inflammatory markers were measured at baseline and after 6 and 12 months. Women allocated to the home-based exercise group received a booklet explaining the physical exercises to be practiced at home at least 3 times per week, 40 minutes per session, at low-to-moderate intensity. All participants received dietary counseling aimed at reducing caloric intake by 100-300 calories per day, with a normal distribution of macro-nutrients (26-28% of energy as fat). Clinicaltrials.gov: NCT01206413 RESULTS: The home-based exercise group showed a significantly greater reduction in weight and body mass index at six months, but no difference between groups was observed thereafter. With regard to the inflammatory markers, a greater but non-statistically significant reduction was found for C-reactive protein in the home-based exercise group at six months; however, this difference disappeared after adjusting for weight change. No differences in adiponectin were found at the 6- or 12-month follow-up.
Conclusion:
Small-volume, home-based exercise did not promote changes in inflammatory markers independent of weight change.
