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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...

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Related Experiment Video

Updated: May 7, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
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Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

Quantitative SPECT/CT: SPECT joins PET as a quantitative imaging modality.

Dale L Bailey1, Kathy P Willowson

  • 1Department of Nuclear Medicine, Royal North Shore Hospital, Faculty of Health Sciences, University of Sydney, Sydney, Australia, dale.bailey@sydney.edu.au.

European Journal of Nuclear Medicine and Molecular Imaging
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Quantitative single photon emission computed tomography (SPECT)/CT imaging is now feasible. Routine corrections enable accurate SPECT scans comparable to positron emission tomography (PET), paving the way for new clinical applications.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiophysics

Background:

  • Combined modality single photon emission computed tomography (SPECT)/CT cameras have renewed interest in quantitative SPECT.
  • Historically, quantitative SPECT has been limited by the lack of readily available body density and photon transport data.
  • Photon attenuation and scattering effects have hindered accurate SPECT imaging for decades.

Purpose of the Study:

  • To validate techniques for producing quantitative SPECT reconstructions using routinely available X-ray CT data.
  • To demonstrate that SPECT imaging can achieve quantitative accuracy comparable to positron emission tomography (PET).
  • To highlight the emergence of intrinsically quantitative SPECT/CT systems.

Main Methods:

  • Utilizing X-ray CT data for attenuation correction in SPECT imaging.
  • Implementing routine corrections for attenuation, scattering, resolution recovery, dead time, and radioactive decay.
  • Cross-calibration to ensure SPECT images are in absolute units (kBq.ml(-1)).

Main Results:

  • Quantitative SPECT reconstructions have been validated using integrated SPECT/CT data.
  • SPECT scans can now be produced with quantitative accuracy equivalent to PET scans.
  • Despite lower spatial resolution and sensitivity than PET, quantitative SPECT is achievable.

Conclusions:

  • Quantitative SPECT imaging is now technically feasible due to advances in SPECT/CT technology and correction algorithms.
  • The availability of accurate SPECT reconstructions is expected to drive the development of clinical applications.
  • The focus on intrinsically quantitative SPECT/CT systems promises to enhance diagnostic capabilities in nuclear medicine.