Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to individual...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevention of arterial catheter-related bloodstream infections: current evidence and future directions.

Critical care (London, England)·2026
Same author

Central venous access device-associated complication costs in paediatric cancer care.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Nurses' Clinical Decision-Making During Peripherally Inserted Central Catheter Dressing Application and Removal: A Qualitative Study.

Seminars in oncology nursing·2026
Same author

An international randomised controlled trial of a novel antimicrobial dressing for peripheral intravenous catheters (ProP trial).

Antimicrobial resistance and infection control·2026
Same author

Changing catheter locking solution practice in paediatric cancer care: barriers, enablers and strategies for implementation.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026
Same author

Better outcomes for the older surgical patient trial (BOOST): protocol for a hybrid type 1 effectiveness-implementation trial of an embedded geriatric perioperative service within emergency and elective surgery in an Australian tertiary referral hospital.

BMJ open·2026

Related Experiment Video

Updated: May 7, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Optimal timing for intravascular administration set replacement.

Amanda J Ullman1, Marie L Cooke, Donna Gillies

  • 1NHMRC Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Griffith Health Institute, Griffith University, 170 Kessels Road, Brisbane, Queensland, Australia, 4111.

The Cochrane Database of Systematic Reviews
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Replacing intravenous administration sets less frequently may reduce bloodstream infections. However, infrequent replacement may increase mortality in neonates. Evidence quality was generally low to moderate.

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Related Experiment Videos

Last Updated: May 7, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Catheter-associated infections, including bacteraemia, are a risk in hospitalized patients.
  • The frequency of replacing administration sets may influence infection rates.

Purpose of the Study:

  • To determine the relationship between administration set replacement frequency and microbial colonization, infection, and mortality rates.

Main Methods:

  • Systematic review and meta-analysis of randomized and controlled clinical trials.
  • Searched multiple databases (CENTRAL, MEDLINE, CINAHL, EMBASE) and included 16 studies with 5001 participants.
  • Assessed outcomes including catheter-related infections, bloodstream infections, colonization, and mortality.

Main Results:

  • Infrequent administration set replacement was associated with a reduced rate of bloodstream infections.
  • No significant differences in catheter or infusate colonization were found.
  • Increased mortality was observed in neonates with infrequent administration set replacement.

Conclusions:

  • Administration sets without lipids, blood, or blood products may be safely used up to 96 hours.
  • Infrequent replacement poses a mortality risk in neonates.
  • Evidence quality from included studies was predominantly low to moderate.