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Updated: May 7, 2026
Methanol-Based Whole-Mount Preparation for the Investigation of Retinal Ganglion Cells
Published on: April 7, 2023
An unusual case of bilateral multifocal retinal pigment epithelial detachment with methanol-induced optic neuritis
Ratnesh Ranjan1, Rajnath Kushwaha, Ramesh Chandra Gupta
1Department of Ophthalmology, GSVM Medical College, Kanpur, 208002, India, drratnesh16@gmail.com.
Purpose:
To describe an unusual case of methanol-induced optic neuritis with bilateral multifocal extrafoveal serous retinal pigment epithelial (RPE) detachment.
Methods:
Single case report.
Case Report:
A 40-year-old male presented with acute bilateral loss of vision and history of consumption of adulterated alcohol. On examination, his vision was perception of light in the right eye and finger counting at 1-ft distance in the left eye. Pupillary reactions were sluggish. The optic discs were normal. An elevated lesion with subretinal serous fluid was present over macula adjacent to superior major vessel arcade in the right eye, which was confirmed as a large extrafoveal RPE detachment on fluorescein angiography. There were two more small RPE detachments in the right eye as well as in the left eye. All RPE detachments were extrafoveal in location. The patient was managed medically with intravenous methylprednisolone (1 g) in 500 ml of ringer lactate for three consecutive days. After three doses, visual acuity of both eyes was recorded as 20/20.
Conclusion:
We herein report an unusual case of bilateral multifocal extrafoveal serous RPE detachment in a patient of methanol-induced optic neuritis. RPE detachments may be due to the toxic effect of methanol metabolites.
