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Updated: May 7, 2026
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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis
1Department of Endocrinology, Shengjing Hospital of China Medical University, Sanhao Street, Shenyang, 110004, China, wuboendo@126.com.
Summary
The p53 Arg72Pro polymorphism may increase thyroid cancer risk, particularly the ProPro genotype. This meta-analysis found a significant association only under the recessive genetic model, suggesting a potential link between this gene variant and thyroid cancer development.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The p53 gene, a critical tumor suppressor, plays a role in various cancers, including thyroid cancer.
- Conflicting findings exist regarding the association between the p53 Arg72Pro polymorphism and thyroid cancer risk.
Purpose of the Study:
- To conduct a meta-analysis to precisely assess the association between the p53 Arg72Pro polymorphism and thyroid cancer risk.
- To consolidate evidence from existing case-control studies to provide a clearer understanding of this genetic association.
Main Methods:
- A comprehensive literature search was performed on PubMed and Web of Science databases up to March 2013.
- Eight case-control studies comprising 874 thyroid cancer cases and 1,891 controls were included in the meta-analysis.
- Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to evaluate the strength of the association under different genetic models.
Main Results:
- A significant association between the p53 Arg72Pro polymorphism and thyroid cancer risk was observed exclusively under the recessive genetic model (ProPro vs. ArgArg/ArgPro: OR=1.83, P=0.034).
- No significant associations were found under the dominant, co-dominant, or allele models.
- Subgroup analyses by ethnicity indicated no significant association in either Caucasian or Asian populations.
Conclusions:
- The p53 Arg72Pro polymorphism, specifically the ProPro genotype, may be a risk factor for thyroid cancer.
- Further research is warranted to elucidate the precise role of this polymorphism in thyroid tumorigenesis, considering potential ethnic variations.
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