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Updated: May 7, 2026
11:51
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules.
Valentina Oliveri1, Antonino Puglisi, Maurizio Viale
1Dipartimento di Scienze Chimiche, University of Catania, Viale A. Doria 6, 95125 Catania (Italy); Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QJ (UK).
Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 17, 2013
Summary
New 8-hydroxyquinoline-cyclodextrin compounds show antioxidant and superoxide dismutase (SOD) mimicking activity. These metal complexes offer potential therapeutic benefits for neurodegenerative diseases and cancer by addressing metal imbalance and oxidative stress.
Area of Science:
- Medicinal Chemistry
- Nanotechnology
- Neuroscience
Background:
- 8-hydroxyquinolines are being re-evaluated for therapeutic potential in cancer and neurodegenerative diseases.
- Metal dyshomeostasis and oxidative stress are key factors in various disorders.
- β-cyclodextrins can enhance drug properties like solubility.
Purpose of the Study:
- To synthesize and characterize novel β-cyclodextrin conjugates of 8-hydroxyquinolines and their metal complexes.
- To evaluate the antioxidant and superoxide dismutase (SOD) mimicking activities of these hybrid systems.
- To assess the therapeutic potential of these compounds for diseases involving metal imbalance and oxidative stress.
Main Methods:
- Spectroscopic characterization of synthesized β-cyclodextrin-8-hydroxyquinoline conjugates and their copper(II) and zinc(II) complexes.
- Evaluation of antioxidant properties.
- Assessment of superoxide dismutase (SOD) mimicking activity.
- Cytotoxicity studies.
Main Results:
- Successful synthesis and spectroscopic characterization of three new β-cyclodextrin-8-hydroxyquinoline conjugates and their copper(II) and zinc(II) complexes.
- The hybrid systems exhibited improved aqueous solubility and significant antioxidant activity.
- Copper(II) complexes demonstrated efficient superoxide dismutase (SOD) mimicry.
- Low cytotoxicity was observed for the ligands and their copper(II) complexes, linked to the cyclodextrin moiety.
Conclusions:
- The novel β-cyclodextrin-8-hydroxyquinoline conjugates and their metal complexes possess promising therapeutic potential.
- These compounds can address diseases linked to both metal dyshomeostasis and oxidative stress.
- The incorporation of β-cyclodextrin enhances solubility and reduces cytotoxicity, improving their drug-like properties.
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