Related Experiment Video
Updated: May 7, 2026

Qualitative and Quantitative Analysis of Siderophore Production from Pseudomonas aeruginosa
Published on: March 15, 2024
Aspergillus fumigatus SidJ mediates intracellular siderophore hydrolysis
Mario Gründlinger1, Fabio Gsaller, Markus Schrettl
1Division of Molecular Biology.
Abstract:
Siderophore-mediated iron handling is crucial for the virulence of Aspergillus fumigatus. Here we identified a new component of its siderophore metabolism, termed SidJ, which is encoded by AFUA_3G03390. The encoding gene is localized in a siderophore biosynthetic gene cluster that is conserved in a variety of fungi. During iron starvation, SidJ deficiency resulted in decreased growth and increased intracellular accumulation of hydrolysis products of the siderophore fusarinine C. The implied role in siderophore hydrolysis is consistent with a putative esterase domain in SidJ, which now represents the first functionally characterized member of the DUF1749 (domain of unknown function) protein family, with members found exclusively in fungi and plants.
More Related Videos
12:08Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
Published on: March 18, 2012
12:36High-throughput Siderophore Screening from Environmental Samples: Plant Tissues, Bulk Soils, and Rhizosphere Soils
Published on: February 9, 2019
Related Concept Videos
Sulfur Assimilation
Antifungal Agents
Microbes and Other Elemental Cycles
Fungal Phylum Microsporidia
Acid Mine Drainage
Microbes and the Sulfur Cycle