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Management of disseminated choroid plexus papilloma: a case study
Guss Zachary1, Jallo George, Blakely Jaishri
1Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, Maryland.
Insights
Choroid plexus papilloma (CPP), a rare adult brain tumor, was treated with craniospinal irradiation (CSI) in an unusual disseminated case. The adult patient achieved 3 years of disease progression-free survival after CSI.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Choroid plexus papilloma (CPP) is a rare, low-grade neoplasm of the choroid plexus, predominantly affecting children and accounting for less than 1% of adult brain tumors.
- Disseminated CPP in adults is exceptionally rare, posing unique treatment challenges.
Observation:
- This report details a unique case of disseminated choroid plexus papilloma in an adult patient.
- The patient had undergone near-total resection 8 years prior to the current presentation.
Findings:
- Craniospinal irradiation (CSI) was delivered to the adult patient with disseminated CPP.
- The patient achieved a 3-year duration of disease progression-free survival following CSI completion.
Implications:
- Craniospinal irradiation may represent a viable treatment option for rare cases of disseminated adult choroid plexus papilloma.
- This case highlights the potential for long-term disease control in adult CPP with advanced treatment modalities.
Abstract:
Choroid plexus papilloma (CPP) is a low-grade neoplasm of the choroid plexus that typically occurs in childhood and comprises under 1% of adult brain tumors. In this article, we report our experience delivering craniospinal irradiation (CSI) to a highly unusual case of disseminated CPP in an adult patient 8 years after an initial near total resection. The patient remains free of disease progression 3 years after completing radiation.