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Updated: May 7, 2026

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Enhanced detection of high-mass proteins by using an active pixel detector
Shane R Ellis1, Julia H Jungmann, Donald F Smith
1Biomolecular Imaging Mass Spectrometry, FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam (The Netherlands).
Abstract:
Flying high: Application of an active pixel detector with high charge sensitivity to a linear time-of-flight mass spectrometer results in enhanced detection of high-mass proteins (such as Immunoglobulin G; IgG) using a conventional microchannel plate detection system. This technique thus provides a means to extend the mass range of such detectors as well as allowing direct visualization of mass-dependent ion-focusing phenomena.
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