Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
Xiaoyun Hong1, Liangming Wei, Fei Wu
1Department of Neurology, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, 1665 Kongjiang Road, Shanghai, People’s Republic of China.
Abstract:
Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation.
Related Concept Videos
Transdermal Drug Delivery Systems
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Modified-Release Drug Delivery Systems: Site-Targeted
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Stimuli-Activated

