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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Gray matter is targeted in first-attack multiple sclerosis.

Steven E Schutzer1, Thomas E Angel, Tao Liu

  • 1Departments of Medicine, and Epidemiology and Biostatistics, Rutgers University New Jersey Medical School, Newark, New Jersey, United States of America.

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|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Early multiple sclerosis (MS) involves gray matter, not just white matter. Cerebrospinal fluid analysis reveals proteins linked to neuron and synapse dysfunction in first-attack MS patients.

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Area of Science:

  • Neuroimmunology
  • Neurology
  • Biochemistry

Background:

  • The precise cause and early pathogenesis of multiple sclerosis (MS) remain elusive.
  • The role of gray matter involvement in the initial stages of MS is debated, with conflicting imaging study results.
  • Understanding early molecular changes is crucial for predicting MS onset and progression.

Purpose of the Study:

  • To investigate objective molecular evidence of gray matter involvement in the cerebrospinal fluid (CSF) of patients experiencing their first clinical attack of MS.
  • To compare protein profiles in the CSF of early-stage MS patients with those of established relapsing-remitting MS patients and healthy controls.

Main Methods:

  • High-resolution mass spectrometry was employed to analyze proteins in the CSF.
  • Two independent cohorts of first-attack MS patients were analyzed.
  • CSF protein profiles were compared between first-attack MS, relapsing-remitting MS, and control groups.

Main Results:

  • CSF proteins in first-attack MS patients showed differential enrichment of gray matter components, including axon, neuron, and synapse proteins.
  • Myelin-associated proteins did not significantly differentiate between the studied groups.
  • These molecular findings provide objective evidence supporting early gray matter involvement.

Conclusions:

  • Gray matter dysfunction is implicated early in the course of multiple sclerosis.
  • Early gray matter involvement may be integral to the manifestation of the initial clinical attack in MS.
  • These findings highlight potential biomarkers for early MS detection and understanding disease initiation.