Suramin: a potential therapy for diabetic nephropathy
Midhun C Korrapati1, Lauren A Howell, Lauren H Howell
1Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Plos One
|September 17, 2013
Summary
Delayed suramin treatment reduced kidney injury in a type 2 diabetic nephropathy mouse model. This drug attenuated inflammation and fibrosis, improving kidney function in diabetic mice.
Area of Science:
- Nephrology
- Pharmacology
- Diabetology
Background:
- Type 2 diabetic nephropathy (T2DN) is a major complication of diabetes.
- Leptin receptor deficient C57BLKS/J db/db mice serve as a model for T2DN.
- Suramin is a drug with established use in treating trypanosomiasis.
Purpose of the Study:
- To investigate the renoprotective effects of delayed suramin administration in a T2DN mouse model.
- To assess suramin's impact on inflammation, fibrosis, and renal function markers.
Main Methods:
- Diabetic (db/db) and control (db/m) mice received suramin or saline.
- Evaluated body weight, blood glucose, urinary protein, and creatinine clearance.
- Assessed kidney pathology, inflammation (NF-κB, ICAM-1), fibrosis (TGF-β1, α-SMA), and collagen deposition.
Main Results:
- Diabetic mice showed increased markers of inflammation and fibrosis compared to controls.
- Suramin treatment significantly reduced these markers in younger diabetic mice.
- In older diabetic mice, suramin improved creatinine clearance and reversed histological damage.
Conclusions:
- Delayed suramin administration attenuated inflammation and fibrosis in a T2DN mouse model.
- Suramin demonstrated potential for improving renal function in T2DN.
- These findings support exploring suramin as a therapeutic agent for T2DN.
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