Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent
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Updated: May 7, 2026
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Published on: September 22, 2019
Krisana Asano1, Sayuri Yoshimura, Akio Nakane
1Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Abstract:
Proteoglycan (PG) extracted from salmon nasal cartilage has potential to be a prophylactic agent. Daily oral administration of the PG attenuates systemic inflammatory response in the experimental mouse models. In this study, we applied the culture-independent approach to investigate an alteration of intestinal microbiota composition in PG-administered mice. The results indicated that the population level of bacilli increased in the small and large intestine upon PG administration. On the other hand, the population level of clostridia decreased in the large intestine. The proportion of bacteria that are able to ferment saccharides and produce short-chain fatty acids increased in the small intestine and decreased in the large intestine. Importantly, population level of probiotic lactobacilli and bacteria exhibiting the immunomodulatory effect increased in the PG-administered mice. In addition, several disease-associated bacteria decreased upon PG administration. These results provided an understanding of the specific role of PG involved in host immune modulation and supported our hypothesis that daily oral administration of PG improves the overall balance in composition of the intestinal microbial community.
Insights
Salmon proteoglycan (PG) supplementation alters gut microbiota, increasing beneficial bacteria like lactobacilli. This oral administration of PG shows potential for improving gut health and immune modulation.
Area of Science:
- Microbiology
- Immunology
- Biochemistry
Background:
- Proteoglycans (PG) from salmon nasal cartilage show promise as prophylactic agents.
- Oral administration of PG has been shown to reduce systemic inflammation in mouse models.
Purpose of the Study:
- To investigate the impact of oral PG administration on intestinal microbiota composition using a culture-independent approach.
- To understand the role of PG in host immune modulation via gut microbiota alterations.
Main Methods:
- Culture-independent analysis of intestinal microbiota in mice.
- Comparison of microbiota composition between PG-administered and control groups.
Main Results:
- Increased populations of bacilli and probiotic lactobacilli in the intestines of PG-treated mice.
- Decreased populations of clostridia and certain disease-associated bacteria.
- Altered proportions of saccharide-fermenting bacteria, with increases in the small intestine and decreases in the large intestine.
Conclusions:
- Oral administration of salmon proteoglycan beneficially modulates intestinal microbiota composition.
- PG influences the gut microbial community, potentially contributing to its immunomodulatory and prophylactic effects.
- The study supports PG's role in improving the overall balance of the intestinal microbial community.
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