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Updated: May 7, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Pediatric Mechanical Support with an External Cardiac Compression Device

Minoo N Kavarana1, Howard M Loree, Robert B Stewart

  • 1Department of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.

Journal of Cardiovascular Diseases & Diagnosis
|September 17, 2013
PubMed

Insights

The PediBooster, a novel pediatric cardiac support device, shows promise in stabilizing acute right ventricular dysfunction. Further research is needed to optimize its design for improved ventricular filling during support.

Area of Science:

  • Biomedical Engineering
  • Pediatric Cardiology
  • Medical Devices

Background:

  • Acute Postcardiotomy Shock (PCS) presents a critical challenge in pediatric cardiac surgery.
  • Existing treatments for PCS have limitations, necessitating novel therapeutic approaches.
  • Biventricular Assist Devices (BiVAD) offer potential for hemodynamic support in pediatric patients.

Purpose of the Study:

  • To evaluate the feasibility and efficacy of the PediBooster, a novel pediatric external cardiac compression device.
  • To assess the PediBooster's performance in a porcine model of acute right ventricular dysfunction.
  • To determine the stability and functional outcomes of the PediBooster in supporting pediatric hearts.

Main Methods:

  • Development and testing of the PediBooster extracardiac wrap with a novel hydrogel coating.
  • Utilized a porcine model (5.1 ± 0.3 kg) with induced acute right ventricular dysfunction via ASD and PA banding.
  • Collected hemodynamic data, transesophageal echocardiography (TEE), video recordings, and cardiac histology over 2-16 hour support durations.

Main Results:

  • The PediBooster demonstrated stable support for up to 16 hours in the pediatric model.
  • TEE and video data confirmed good attachment and function of the wrap.
  • Wrap-induced end-diastolic restriction was observed in 3 out of 4 animals, indicating a need for design optimization.

Conclusions:

  • The PediBooster shows potential as a palliative therapy for pediatric Postcardiotomy Shock.
  • The developed congenital heart disease model is suitable for further chronic studies.
  • Adjusting wrap dimensions may improve ventricular filling and mitigate restriction during PediBooster support.

Keywords:
Congenital heart disease modelPediatric mechanical support

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