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Related Experiment Video

Updated: May 7, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Pediatric Mechanical Support with an External Cardiac Compression Device.

Minoo N Kavarana¹, Howard M Loree, Robert B Stewart

¹Department of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.

Journal of Cardiovascular Diseases & Diagnosis

|September 17, 2013

Summary

The PediBooster, a novel pediatric cardiac support device, shows promise in stabilizing acute right ventricular dysfunction. Further research is needed to optimize its design for improved ventricular filling during support.

Keywords:

Congenital heart disease model Pediatric mechanical support

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Published on: August 16, 2021

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Last Updated: May 7, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

Area of Science:

Biomedical Engineering
Pediatric Cardiology
Medical Devices

Background:

Acute Postcardiotomy Shock (PCS) presents a critical challenge in pediatric cardiac surgery.
Existing treatments for PCS have limitations, necessitating novel therapeutic approaches.
Biventricular Assist Devices (BiVAD) offer potential for hemodynamic support in pediatric patients.

Purpose of the Study:

To evaluate the feasibility and efficacy of the PediBooster, a novel pediatric external cardiac compression device.
To assess the PediBooster's performance in a porcine model of acute right ventricular dysfunction.
To determine the stability and functional outcomes of the PediBooster in supporting pediatric hearts.

Main Methods:

Development and testing of the PediBooster extracardiac wrap with a novel hydrogel coating.
Utilized a porcine model (5.1 ± 0.3 kg) with induced acute right ventricular dysfunction via ASD and PA banding.
Collected hemodynamic data, transesophageal echocardiography (TEE), video recordings, and cardiac histology over 2-16 hour support durations.

Main Results:

The PediBooster demonstrated stable support for up to 16 hours in the pediatric model.
TEE and video data confirmed good attachment and function of the wrap.
Wrap-induced end-diastolic restriction was observed in 3 out of 4 animals, indicating a need for design optimization.

Conclusions:

The PediBooster shows potential as a palliative therapy for pediatric Postcardiotomy Shock.
The developed congenital heart disease model is suitable for further chronic studies.
Adjusting wrap dimensions may improve ventricular filling and mitigate restriction during PediBooster support.