Related Experiment Video
Updated: May 7, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy
Saad Makhseed1, Miloslav Machacek, Waleed Alfadly
1Department of Chemistry, Kuwait University, P.O. Box 5969, Safat, 13060, Kuwait. saad.makhseed@ku.edu.kw.
Abstract:
Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and high singlet oxygen quantum yield in water (ΦΔ > 0.33). The in vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) and low dark toxicity to non-cancerous cells (TC50 = 395 μM).
More Related Videos
11:04An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
09:45Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015