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Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
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Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
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Published on: August 11, 2021

Suicide and the polyamine system.

Jeffrey A Gross1, Gustavo Turecki

  • 1McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 boul. Lasalle, Verdun, Quebec, H4H 1R3, Canada. gustavo.turecki@mcgill.ca.

CNS & Neurological Disorders Drug Targets
|September 18, 2013
PubMed
Summary
This summary is machine-generated.

The polyamine system may be dysregulated in suicidal behaviors. Research suggests alterations in the polyamine system in mental disorders and suicidal phenotypes, offering potential intervention targets.

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Last Updated: May 7, 2026

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Area of Science:

  • Neurobiology
  • Psychiatry
  • Molecular Biology

Background:

  • Suicide is a major global public health issue.
  • Understanding its neurobiology is crucial for identifying etiological factors and developing interventions.
  • The polyamine system is increasingly implicated in suicidal behaviors.

Purpose of the Study:

  • To review research on polyamine system alterations in mental disorders and suicidal behaviors.
  • To highlight molecular mechanisms potentially involved in suicide.
  • To suggest future research directions.

Main Methods:

  • Review of existing animal and human post-mortem brain tissue research.
  • Analysis of studies investigating polyamine system alterations in mental disorders.
  • Examination of research specifically focusing on suicide.

Main Results:

  • Evidence suggests a dysfunctional polyamine stress response system in animals.
  • Post-mortem human brain studies indicate molecular mechanisms related to suicide.
  • Alterations in the polyamine system are observed in various mental disorders and behavioral phenotypes.

Conclusions:

  • The polyamine system is a potential target for understanding and intervening in suicidal behaviors.
  • Further research is needed to elucidate the precise role of polyamines in suicide neurobiology.
  • Investigating polyamine pathways may lead to novel therapeutic strategies for suicide prevention.